Current research covers a wide portfolio of basic, translational and clinical research focussing on: Adrenal and gonadal steroids; thyroid cancer; thyroid dysfunction; fetal and reproductive endocrinology; pituitary disease; auto-immunity; genetics of diabetes and insulin resistance; ongoing studies employ a broad range of in vitro and in vivo approaches including mouse transgenic and knock-out models as well as clinical translational and interventional studies carried out in the Wellcome Trust Clinical Research Facility immediately adjacent to the Institute of Biomedical Research, the lab base for most of the endocrine and diabetes groups; clinical research is also enhanced by close interaction with the University Hospital and cohort and database studies (thyroid disease, pituitary disease, and adrenal disease); hormones and genes research (endocrinology, diabetes and metabolism and genetics) represents a significant research strength within the College of Medical and Dental Sciences as evidenced by the fact 75% of submission to the Other Hospital Based Clinical Subjects UoA for RAE 2008 was considered internationally excellent or world leading.