Research in the School of Immunity and Infection is themed as follows: 1) Immunology: Cellular and molecular interactions in in vivo inducing and regulating immune responses; thymocyte/stromal cell interactions in t cell development and selection; chemokine regulation of immune responses; regulation of immune responses to self proteins focusing in particular on regulatory t cells and type 1 diabetes; trans-membrane and intracellular signalling inducing lymphocyte cell proliferation and differentiation; immune regulation for bacterial infection; clinical and diagnostic immunology; 2) inflammation: (rheumatology): T lymphocyte control of immune responses with special reference to inflammatory joint and eye disease; regulation of neutrophil apoptosis during inflammation and the effect of ageing on immune function; clinical rheumatology-systemic lupus erythematosus; (renal immunobiology): mechanisms of dysregulated neutrophil and lymphocyte function during pathogenesis of autoimmune renal disease, particularly vasculitis; (ophthalmology): the involvement of lymphocytes, cytokines and inflammatory eye disease; regulation of immune responses by the ocular microenvironment; 3) liver disease and hepatitis C immunobiology: immune mechanisms in inflammatory liver disease; stem cells and liver disease; molecular biology and pathogenesis of HCV; 4) stem cell biology and gene regulation: haemopoietic stem control mechanisms; histone acetylation, chromatin structure and the control of gene expression; chromatin remodelling and transcriptional regulation of drosophila blood development; control mechanisms in angiogenesis; regulation of haematopoiesis; 5) microbial infection and antibiotic resistance: the mechanism of action and resistance to antibacterial agents; microbial genomics and pathogenesis; immunological defence against mycobacterial infection.