Staff research interests include: Molecular mechanisms underlying platelet activation in health and disease; angiogenesis; atherosclerosis; hypertension in pregnancy; peripheral, arterial and venous diseases; evaluating standard/endoscopic surgical techniques in treatment of chronic venous insufficiency; role of arterial wall motion abnormalities in the pathogenesis of atherosclerosis/aneurismal disease; development of complications in patients undergoing major vascular surgery; mechanisms of angiogenesis in ischaemia; cardiovascular adaptations to low temperature; substrate utilisation of the working heart; monitoring microcirculatory disturbances associated with inflammatory conditions (ischaemia-reperfusion (i/r) injury); mechanisms underlying oxygen sensitivity in carotid body and pulmonary artery; regulation of the circulation in normal human subjects and in patient groups; adhesive and mechanical properties of circulating blood cells; in vitro modelling of the cellular pathology of atherosclerosis; atrial fribrillation (epidemiology, pathophyiology, thromboprophylaxis, psychological morbility, etc), hypertension, heart failure and clinical/experimental thromboembolism.